منابع مشابه
IL-6 and lipid metabolism
Interleukin-6 (IL-6) plays essential roles not only in the immune response, but also in hematopoiesis, and in the central nervous system. Dysregulated production of IL-6 has been found in chronic inflammatory autoimmune diseases such as rheumatoid arthritis (RA). Many reports have indicated that lipid levels, such as total cholesterol and triglyceride levels, are changed under inflammatory cond...
متن کاملVitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism.
Diet-induced obesity (DIO) and insulin resistance in mice are associated with proteinuria, renal mesangial expansion, accumulation of extracellular matrix proteins, and activation of oxidative stress, proinflammatory cytokines, profibrotic growth factors, and the sterol regulatory element binding proteins, SREBP-1 and SREBP-2, that mediate increases in fatty acid and cholesterol synthesis. The ...
متن کاملAltered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy.
Animal models link ectopic lipid accumulation to renal dysfunction, but whether this process occurs in the human kidney is uncertain. To this end, we investigated whether altered renal TG and cholesterol metabolism results in lipid accumulation in human diabetic nephropathy (DN). Lipid staining and the expression of lipid metabolism genes were studied in kidney biopsies of patients with diagnos...
متن کاملLipid metabolism in Drosophila: development and disease.
Proteins, nucleic acids, and lipids are three major components of the cell. Despite a few basic metabolic pathways, we know very little about lipids, compared with the explosion of knowledge about proteins and nucleic acids. How many different forms of lipids are there? What are the in vivo functions of individual lipid? How does lipid metabolism contribute to normal development and human healt...
متن کاملCauses of dysregulation of lipid metabolism in chronic renal failure.
End-stage renal disease (ESRD) is associated with accelerated atherosclerosis and premature death from cardiovascular disease. These events are driven by oxidative stress inflammation and lipid disorders. ESRD-induced lipid abnormalities primarily stem from dysregulation of high-density lipoprotein (HDL), triglyceride-rich lipoprotein metabolism, and oxidative modification of lipoproteins. In t...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 1980
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.69.1264